We are finally moving from Beta to Release Candidate (RC). Are you ready? If you have any custom themes or plugins, have you tested them? Have you checked out all the details of the release yet? Release Candidate is usually the stage where I start switching over my sites, starting with the least complicated. You can do the same on a simple site, and play around a bit. I wouldn’t recommend this for anyone with a complicated site, lots of jQuery plugins, or a site that would hurt if it went down. But in those circumstances, you should have a copy test site, and should already know if WP3.3 is going to cause any issues.